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This tool is provided by Epson Inc., and allows you to reset WIC to a factory state when the ink counter stops counting. You do not need a license to download WIC Resetter.Phospholipid transfer protein is secreted by lung macrophages and is functionally modulated by interferon gamma.
Phospholipid transfer protein (PLTP) is a structurally unique protein present in plasma, the testis, and in monocyte-derived and other leukocyte populations. A PLTP cDNA was isolated from a human testis library. PLTP synthesized in COS-1 cells was released into the medium and was N-glycosylated. A single polypeptide of 55 kDa was recognized by monoclonal antibody PLTP. Western blotting, using polyclonal antibodies, detected a protein of similar size in human lung macrophages. By ELISA and Northern blotting, PLTP was detected in the bronchoalveolar lavage fluid and sera of rat, mouse, pig, and human. Lung macrophages were positive for PLTP protein by immunohistochemistry, and contained 5-10% of the total protein content of these cells. The PLTP protein in lung macrophages was secreted into the medium, and the amount secreted was increased in response to interferon gamma. In an in vitro assay, PLTP caused the displacement of lipids from phosphatidylcholine-containing vesicles by a factor of 3.0, with an apparent Km of 0.6 microM and a Vmax of 7 micromol/min/mg of protein. Studies on PLTP activity in the presence and absence of lipids may provide further insights into the role of PLTP in atherosclerosis.Q:
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